After a stroke, there is often an accumulation of fluid in the brain (cerebral edema) that can cause life-threatening brain swelling. Researchers at the University of Würzburg have now found a possible new therapeutic approach to treat these fluid collections effectively.

Normally, cerebral edema, which are formed as a brain tumor or multiple sclerosis-thrust, successfully treated with so-called glucocorticoids (eg cortisone). In stroke, the same drugs prove ineffective or even harmful. Carola Förster and team have now been able to elucidate the cause of the difference in effectiveness.

The oxygen deprivation that occurs during a stroke, leads to the lymph vessels in the brain (brain endothelial cells) to change. It builds a certain protein complex (proteasome) the glucocorticoid receptors, which mediate the effects of glucocorticoid drugs, over-heavily. The cells lose the ability to respond to the therapy. Early blockade of the proteasome could therefore restore the susceptibility of the endothelial cells of glucocorticoid. Even then in stroke treatment with cortisone and other steroids would be possible again.

Initial tests on mice ran promising results so far. The experiments could provide the basis for this to brain swelling in stroke patients treated in the future to do better. Until a drug for people in the market, according to estimates by Carola Förster, however, took another ten years.

A stroke is usually caused by a sudden disturbance of blood supply in the brain. The nerve cells are thus deprived of oxygen and nutrients – they die. Currently, stroke is the second leading cause of death in Germany.

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One in five primary school students of grades one to four according to a study suffers from sleep problems. In most cases, however, only the resulting symptoms such as poor concentration, hyperactivity or anxiety, not with the sleep problem itself, said the Cologne Sleep Specialist Alfred Wiater on Friday at a symposium in Warnemünde. He appealed to doctors and parents, especially at an early age to pay attention to sleep habits and to consider problems sleep expert.
Sleep disorders may have many causes, said Frank Kirchhoff, director of the Children Sleep Laboratory, at the Rostock Clinic South City. In some cases, they are genetic, sometimes they are also due to snoring, for example, due to large tonsils and adenoids, to nocturnal seizures or obesity. In the sleep laboratory every year around 500 children aged between 0 and 18 years are examined, overnight, all bodily functions documented.

“In one case, moving a child sleeping in the legs often violently, so it was constantly disturbed during deep sleep,” said Kirchhoff. With the little sleep during the day it was unfocused and constantly tired, could not sleep at night, however. The reason was lack of iron, the sleep disorder was resolved and the overall health improved considerably.

Sleep doctors advise parents to observe the sleeping habits of their children more closely. “In the interviews for our study, in most cases the children themselves describe their problems very well,” said Wiater, who sits on the board of the Society for Sleep Medicine and Sleep Research. “Only one in three cases, the sleep problems and the Parent.” Good sleep is important but for recreation and also for memory function. Why would such as snoring children often poorer school performance than those who sleep without snoring, Wiater said.

On the basis of a small genetic difference, doctors can apparently predict the extent of disability after a stroke. The report Spanish researchers at the University of Salamanca. The results are published in the online edition of the journal “Journal of Experimental Medicine”.

As a result of a stroke brain cells die, from the so-called neurons. The TP53 gene that controls cell death occurs in the human body is in a R-and P-variant. The difference: the R-variant triggers the cell death more effectively than the P-variant. The researchers studied two groups of stroke patients. Those who had only the R-variant of the cell death gene, suffered a few months after the stroke than subjects with major complaints of the P-variant group. Further investigations showed, isolated brain cells, in which the R-variant active, more susceptible to cell death through lack of oxygen.

The scientists now want to Angeles Almeida clarify whether it is possible using the TP53 variants also draw conclusions on the prognosis of other neuronal diseases such as Alzheimer’s or Parkinson’s.

A stroke occurs when blood flow is disturbed in the brain. This can lead to speech, movement and visual disturbances. Because every brain reacts differently to a stroke, it is now difficult to estimate the long-term consequences.